In vitro activity of anti-leishmanial drugs against Leishmania donovani is host cell dependent
نویسندگان
چکیده
منابع مشابه
In vitro activity of anti-leishmanial drugs against Leishmania donovani is host cell dependent.
OBJECTIVES To evaluate the in vitro activity of anti-leishmanial drugs against intracellular Leishmania donovani amastigotes in different types of macrophages. METHODS Mouse peritoneal macrophages (PEMs), mouse bone marrow-derived macrophages (BMMPhi), human peripheral blood monocyte-derived macrophages (PBM Phi) and differentiated THP-1 cells were infected with L. donovani. Cultures were inc...
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Leishmaniasis remains a major health problem of the tropical and subtropical world. The visceral form causes the most fatalities if left untreated. Dramatic increases in the rates of infection and drug resistance and the non-availability of safe vaccines have highlighted the need for identification of novel and inexpensive anti-leishmanial agents. This study reports that racemoside A, a water-s...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2010
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkp500